Intramolecular Staudinger Ligation: A Powerful Ring

Electronic and Steric Effects on the Rate of the Traceless Notable attributes of this ligation strategy include its ability to generate an amide product without either residual atoms, 3 or racemization, 4 and a high reaction rate. 5 (Diphenylphosphino)methanethiol (1) is the most often used of known reagents for effecting the traceless Staudinger ligation, and has mediated the orthogonal assembly of a Staudinger Ligation for Glycoprotein Synthesis - Creative So far, Staudinger ligation has been applied in diverse fields such as protein immobilization, solid-phase peptide synthesis, stereoselective N-glycosylation, and the synthesis of homogenous glycoproteins. Fig.1 Traceless Staudinger ligation of expressed peptides. (Liu, 2006) Staudinger Ligation for Glycoprotein Synthesis at Creative Biolabs

Reaction Mechanism and Kinetics of the Traceless

An approach combining traceless Staudinger ligation and protease‐catalyzed N‐terminal azidonation has been shown to be efficient for the convergent synthesis of glycopeptides without the cysteine limitation of native chemical ligation. A "traceless" Staudinger ligation for the chemoselective

Mar 12, 2013

Staudinger Ligation for Glycoprotein Synthesis - Creative So far, Staudinger ligation has been applied in diverse fields such as protein immobilization, solid-phase peptide synthesis, stereoselective N-glycosylation, and the synthesis of homogenous glycoproteins. Fig.1 Traceless Staudinger ligation of expressed peptides. (Liu, 2006) Staudinger Ligation for Glycoprotein Synthesis at Creative Biolabs Staudinger Reaction | Chem-Station Int. Ed. Reference: J. Org. Chem. 2004, 69, 4299. J. Am. Chem. Soc. 2005, 127, 2686. Examples; The Staudinger-Bertozzi ligation [1]: Bertozzi developed the Staudinger-then-aza-Wittig reaction shown below and demonstrated its utility in ligating large phosphorescent compounds by the amide bond.This reaction is high yielding and highly chemoselective, offering possibilities for applications in various Traceless Staudinger Ligation for the Synthesis of OVERVIEWUW–Madison researchers previously developed a method of using traceless Staudinger ligation to chemically synthesize proteins (see WARF reference number P00315US).This method is based on the Staudinger reduction, in which a phosphine reduces an azide via an iminophosphorane intermediate. It has been used in the assembly of proteins and for site-specific immobilization of … Phosphine-Based Redox Catalysis in the Direct Traceless